Figure 6.

Case 1. Imaging and histopathological findings. Mediolateral (a,b) and craniocaudal (c,d) mammograms showing a normal right breast and the left breast grossly deformed by an extensive malignant tumour having architectural distortion and no associated calcifications. Handheld ultrasound: a large anechoic malignant tumour with pathologic axillary lymph nodes (e,f). Low-power, large-format histopathology image of a portion of this histologically 102 mm moderately differentiated, diffusely infiltrating carcinoma (g) (H&E staining). Higher-power histopathology images show a classical single-file growth pattern characteristic for “classic infiltrating lobular carcinoma” (h). Histopathology image of the axillary lymph node metastases (i). The immuno-histochemical staining showed strong diffuse oestrogen receptor (j) and progesterone receptor (k) positivity in 95% of the tumour cells, human epidermal growth factor receptor 2 (HER-2) negativity (l), 15% proliferation index (Ki 67) (m), and the absence of E-cadherin (n). 10× magnification: (h,i,k–n); 5× magnification: (j).