Figure 6.

The role of H₂S in inflammation in neurotrauma. TNF, tumor necrosis factor; COX, cyclooxygenase; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; iNOS, inducible nitric oxide synthase; NO, nitric oxide; IL-1β, interleukin-1 beta; NLRP, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing; GSDMD, Gasdermin D; Casp1, caspase-1; Casp3, caspase-3; PKC, protein kinase C; Ca²⁺, calcium ions; CaM, calmodulin; p38, p38 mitogen-activated protein kinase; CD11b\CD18, Mac-1β2 integrin; CcO, cytochrome-c-oxidase. Arrows with a sharp end—positive regulation; arrows with a blunt end—negative regulation.