Figure 1.

CHA induces a stable torpor state upon LPS infection. (A) The core temperature of mice received i.p. injection of saline and three dosages of CHA (0.2 mg/kg, 1 mg/kg, and 1.5 mg/kg). The mice received an i.p. injection of 1.5 mg/kg of CHA, together with or without 4 mg/kg LPS. The core temperature was recorded in (B), and the area under the curve of (B) was plotted in (C). The systolic pressure (D), diastolic pressure (E), and heart rate (F) were also recorded in all four groups. CHA: N6-cyclohexyladenosine. n.s. = not significant. p < 0.05 for *.