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. 2023 Jul 3;24(13):11036. doi: 10.3390/ijms241311036

Figure 5.

Figure 5

CHA-induced torpor inhibits inflammatory responses of macrophages and oxidative stress in brain endothelial cells. (A–C) mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in macrophages at 37 °C and 30 °C after LPS stimulus with or without CHA. (D,E) mRNA levels of IL-6 and SOD2 in bEnd.3 cells at 37 °C and 30 °C after LPS stimulus with or without CHA. (F) Mitochondria activity is evidenced by the mitotracker probe under the same settings of (D,E). (G) Quantification of mitotracker intensity in (F). n.s. = not significant. Dotted lines are just to separate two groups for easier understanding. p < 0.05 for *. p < 0.05 for # vs. the saline group. Scale bar = 10 µm in (F).