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Extrinsic pathway of apoptosis induced by imiquimod (IM). Under normal conditions, basal cell carcinoma cells (BCC) lack CD95, which allows them to elude immunosurveillance. IM upregulates the expression of CD95 and CD95L in BCC cells, triggering the extrinsic pathway of apoptosis through BCC cell–BCC cell and BCC cell–CD4+ T cell contact.
