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. 2023 Jun 28;24(13):10801. doi: 10.3390/ijms241310801

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The plasma PACAP-38 levels in relation to the depth of therapeutic response. The box plot diagram represents the interquartile range and median values. Whiskers indicate the most extreme observations. The individual values are presented with black dots (control group (C), n = 10), downward triangles (patients with stable or progressive disease (SD, PD), n = 17), upward triangles (patients in partial response (PR), n = 10), rhombuses (patients in very good partial response (VGPR), n = 13), hexagons (patients in complete remission (CR), n = 11), and squares (patients with minimal residual disease negativity (MRD neg.), n = 7). For statistical analysis, the Kruskal–Wallis test with Dunn’s multiple comparison was used. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.