Table 6.
The plasma PACAP-38 levels in relation to the therapeutic agents. The Mann–Whitney U test was used for the statistical analysis. IMiDs: immunomodulatory agents, SD: standard deviation.
| Tested Parameters |
Patient Groups | Number of Patients (n) |
PACAP-38 Level: Mean +/− SD (pg/mL) |
Significance (p) |
|---|---|---|---|---|
| IMiDs | Treated | 37 | 199.0 +/− 87.54 | 0.0558 |
| Untreated | 21 | 154.3 +/− 40.80 | ||
| Lenalidomide | Treated | 18 | 228.6 +/− 95.63 | 0.0062 |
| Untreated | 40 | 161.7 +/− 55.43 | ||
| Thalidomide | Treated | 14 | 164.9 +/− 38.48 | 0.3083 |
| Untreated | 44 | 198.6 +/− 82.59 | ||
| Proteasome inhibitor | Treated | 44 | 185.8 +/− 74.11 | 0.4443 |
| Untreated | 14 | 198.7 +/− 66.63 | ||
| Alkylating agents | Treated | 10 | 141.3 +/− 38.16 | 0.0200 |
| Untreated | 48 | 192.8 +/− 71.95 | ||
| Steroid | Treated | 45 | 181.0 +/− 66.77 | 0.1582 |
| Untreated | 13 | 225.6 +/− 104.8 | ||
| Daratumumab | Treated | 4 | 289.6 +/− 150.7 | 0.0773 |
| Untreated | 54 | 174.3 +/− 64.45 |