Figure 5.

Depict the mechanism of experimental endocarditis caused by S. aureus. The process is marked by the crucial role of sequential fibrinogen binding responsible for valve colonization and the critical action of fibronectin-binding that promotes endothelial invasion. FnBPA responsible for fibrinogen and fibronectin binding may advocate cell invasion in vivo endocarditis. Abbreviations; Akt or PKB, protein kinase B, FAK, focal adhesion kinase; P13-k, Phosphoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase. Permission from [12], https://doi.org/10.3390/metabo12080682.