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. 2023 Jun 26;24(13):10670. doi: 10.3390/ijms241310670

Figure 2.

Figure 2

RP54 and CRD-associated mutations in PCARE protein. Schematic representation of missense (red), frameshift (black), and nonsense (green) mutations. In the PCARE structure, colored columns represent the functional motifs: N-myristoylation (Gly2), S-palmitoylation (Cys3), coiled-coil domain (aa 318–333), two RP62 kinase-binding motifs, a WH2 acting binding motif (aa 597–615), three proline-rich regions (EVH1 domain-binding motifs) (aa 805–809, 830–834, 1056–1060), and a nuclear localization signal (aa 1042–1049).