Table 2.
Anti-TBEV activity and chronic cytotoxicity of compounds 3–5.
| R | cmpd | TBEV EC50, μM |
PEK 1 (7 Days) CC50, μM |
cmpd | TBEV EC50, μM |
PEK (7 Days) CC50, μM |
cmpd | TBEV EC50, μM |
PEK (7 Days) CC50, μM |
|---|---|---|---|---|---|---|---|---|---|
| Me | 3a | >100 | >50 | 4a | 27 ± 12 | >50 | - | - | - |
| Bn | 3b | 13 ± 8 | >50 | 4b | >50 | >50 | 5b | 21.7 ± 2.8 | >50 |
| Ph | 3c | >50 | >50 | 4c | 9 ± 2 | >50 | 5c | >50 | >50 |
|
3d | >50 | >50 | 4d | 21 ± 13 | >50 | 5d | 34 ± 4 | >50 |
|
3e | 18 ± 7 | >50 | 4e | 12 ± 7 | >50 | 5e | 10 ± 5 | >50 |
|
3f | >50 | >50 | 4f | 13 ± 6 | >50 | 5f | 29 ± 7 | >50 |
|
3g | >100 | >50 | 4g | >50 | >50 | 5g | 33 ± 15 | >50 |
|
3h | 28 ± 7 | >50 | 4h | 20 ± 11 | >50 | 5h | 12 ± 6 | >50 |
|
- | - | - | 4i | 2.0 ± 0.5 | >50 | 5i | 19 ± 4 | 41.0 ± 1.8 |
|
3j | 20 ± 11 | >50 | 4j | 17 ± 3 | >50 | 5j | 10.0 ± 2.4 | >50 |
|
3k | >100 | >50 | 4k | >50 | >50 | 5k | 20 ± 3 | >50 |
|
3l | >100 | >50 | 4l | 15 ± 4 | >50 | 5l | 36 ± 4 | >50 |
| 6 | 2.29 ± 0.17 | >100 |
1 Porcine embryo kidney cells.