Table 3.
Anti-WNV activity and chronic cytotoxicity of compounds 3–5.
| cmpd | WNV EC50, μM | Vero 1 (7 Days) CC50, μM | cmpd | WNV EC50, μM | Vero (7 Days) CC50, μM | cmpd | WNV EC50, μM | Vero (7 Days) CC50, μM |
|---|---|---|---|---|---|---|---|---|
| 3a | 31.0 ± 2.0 | >50 | 4a | 10 ± 6 | >50 | - | - | - |
| 3b | 9.9 ± 1.5 | >50 | 4b | 16 ± 8 | >50 | 5b | 6.3 ± 1.2 | >50 |
| 3c | 25 ± 7 | >50 | 4c | 2.6 ± 1.4 | >50 | 5c | 18 ± 4 | >50 |
| 3d | 14 ± 5 | >50 | 4d | 3.0 ± 1.9 | >50 | 5d | 14 ± 8 | >50 |
| 3e | 22 ± 4 | >50 | 4e | 4.8 ± 1.0 | >50 | 5e | 4.0 ± 0.6 | >50 |
| 3f | 18 ± 6 | >50 | 4f | 7.1 ± 1.0 | >50 | 5f | 16 ± 10 | >50 |
| 3g | 28.4 ± 2.2 | >50 | 4g | 9.8 ± 2.6 | >50 | 5g | 12 ± 6 | >50 |
| 3h | 21.5 ± 0.9 | >50 | 4h | 7.8 ± 1.0 | 33.28 ± 0.02 | 5h | 17 ± 3 | >50 |
| - | - | - | 4i | 5.3 ± 1.0 | 28.3 ± 2.4 | 5i | 19 ± 11 | >50 |
| 3j | 20.3 ± 0.3 | 31 ± 3 | 4j | 1.3 ± 0.5 | >50 | 5j | 5.9 ± 1.8 | >50 |
| 3k | 6.1 ± 1.3 | >50 | 4k | 10 ± 4 | >50 | 5k | 18 ± 4 | 12.0 ± 2.4 |
| 3l | 11 ± 7 | >50 | 4l | 8 ± 4 | >50 | 5l | >50 | >50 |
| Favipiravir | 102 ± 28 | >1000 |
1 African green monkey kidney cells.