Table 1.
Oral treatment regimens for acute uncomplicated cystitis.
| Drug | Dose and Duration | Common Adverse Effects | |
|---|---|---|---|
| Nitrofurantoin monohydrate macrocrystals |
100 mg twice daily for 5 d | Nausea, headache, gastrointestinal effects | |
| Pivmecillinam | 400 mg twice daily for 5 d | Rash and gastrointestinal upset, including nausea and vomiting | |
| Trimethoprim- sulfamethoxazole |
160/800 mg twice daily for 3 d | Rash, urticaria, nausea, vomiting, hematologic signs |
|
| Fosfomycin tromethamine | 3 g single-dose sachet | Diarrhea, nausea, headache | |
| β-Lactams | The dose varies by agent from 5 to 7 d | Diarrhea, nausea, vomiting, rash, urticaria | |
| Fluoroquinolones | Ciprofloxacin | 500 mg twice daily or 1000 mg once daily for 3 d |
Nausea, vomiting, diarrhea, headache, drowsiness, insomnia, tendon rupture, neuropathy |
| Norfloxacin | 400 mg twice daily for 3–7 d | ||
| Ofloxacin | 200–400 mg twice daily | ||
| Levofloxacin | 750 mg once daily for 3 d | ||