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. 2023 Jun 28;24(13):10753. doi: 10.3390/ijms241310753

Figure 1.

Figure 1

A ketogenic diet alone and in combination with gemcitabine preserves muscle strength and weight in KPC mice. (A) Schematic outline of the survival study design. Once pancreatic tumors were detected, female and male KPC mice were randomized to a control diet (CD), ketogenic diet (KD), CD plus gemcitabine (CG) or KD plus gemcitabine (KG) (n = 16–23/group) until endpoint. (B) Non-fasted blood β-hydroxybutyrate levels at baseline, one and two months after diet initiation. (C) Relative forelimb-grip strength force at baseline, one and two months after diet initiation and (D) gastrocnemius weight are shown for all (left), females only (center) and males only (right) KPC mice fed a control diet (CD), ketogenic diet (KD), CD plus gemcitabine (CG) or KD plus gemcitabine (KG). Values are expressed as mean ± SEM; * p < 0.05, ** p < 0.01.