Table 1.
Parameter estimates from the final linear mixed-effects models for outcome.
| Outcome | ||||
|---|---|---|---|---|
| Model Term | Grip Strength (per Unit of Weight) g/g BW |
Ketone Bodies (mmol/L) | ||
| Estimate (SE) | p-Value | Estimate | p-Value | |
| Intercept | 3.04 (0.11) | <0.001 | 0.487 (0.067) | <0.001 |
| Effect of KD vs. CD (without GEM, at day 30) | −0.17 (0.11) | 0.121 | 0.128 (0.08) | 0.115 |
| Effect of GEM vs. No GEM (with CD, at day 30) | 0.07 (0.093) | 0.436 | −0.148 (0.094) | 0.121 |
| Effect of Time since intervention (in days)(with CD and no GEM) | −0.02 (0.0039) | <0.001 | −0.002 (0.003) | 0.402 |
| Effect of baseline age (in days) | −0.0042 (0.0036) | 0.247 | 0.001 (0.002) | 0.654 |
| Effect of Male vs. Female | −0.35 (0.085) | <0.001 | - | - |
| Effect of baseline outcome | 0.14 (0.073) | 0.066 | 0.016 (0.196) | 0.935 |
| Interaction between KD and GEM | - | - | 0.355 (0.124) | 0.006 |
| Interaction between KD and Time | 0.021 (0.0053) | <0.001 | 0.008 (0.004) | 0.024 |
| Interaction between GEM and Time | - | - | 0.005 (0.004) | 0.222 |
| Interaction between KD, GEM, and Time | - | - | −0.018 (0.005) | 0.002 |
Note: Linear mixed-effects regression models were fitted for repeatedly measured post-treatment outcomes, which included fixed effects for diet, drug, time, and their 2-way and 3-way interactions (if significant), baseline age, sex, baseline outcome, and random intercepts for animal. Abbreviations: CD: control diet; KD: ketogenic diet; GEM: Gemcitabine.