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. 2023 Jun 25;24(13):10629. doi: 10.3390/ijms241310629

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Analysis of the dynamics of DNA replication in MDA-MB-468 and NCI-H295R cells treated with palbociclib. (A,B) Part of chromosome 1 replication timing profiles in MDA-MB-468 cells. The blue line represents control cells treated with mock, the red one cells treated with palbociclib and the green one with ribociclib. Chromosome coordinates are indicated below each profile (M = Mégabase). (C,D) Profile of replication timing for a part of chromosome 9 in NCI-H295R cells. (E) Percentages of the whole genome altered after the treatment with either palbociclib or ribociclib. (F) Stacked histograms representing the proportion of advanced or delayed replicating regions in percentage considering their length after the palbociclib treatment.