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. 2023 Jun 27;24(13):10716. doi: 10.3390/ijms241310716

Figure 3.

Figure 3

Sophora japonica extracts before (KPF-BBR) and after bioconversion reactions (KPF-ABR) reduce cell viability, change morphology, and present an apoptotic effect on grade III glioma cell lines. (A) The NG-97 cell line is treated with different concentrations of KPF-BBR for 24, 48, and 72 h and the inhibitory concentration (IC50) is determined using an MTT assay (800 µM for 72 h). Morphological and nuclear changes are observed especially after 72 h compared with the untreated control cells. (B) NG-97 cells are treated with different concentrations of KPF-ABR for 24, 48, and 72 h, and the IC50 is determined through MTT (600 µM for 72 h). Morphological and nuclear changes are observed especially after 72 h compared with the untreated control cells. The data are presented are the mean ± standard deviation of the experiments performed in triplicate.