Skip to main content
. 2023 Jun 27;24(13):10716. doi: 10.3390/ijms241310716

Figure 4.

Figure 4

Sophora japonica extracts before (KPF-BBR) and after bioconversion reactions (KPF-ABR) reduce cell viability, change morphology, and present an apoptotic effect on the glioblastoma cell line. (A) The U251 cell line is treated with different concentrations of KPF-BBR for 24, 48, and 72 h and the inhibitory concentration (IC50) is determined using an MTT assay (1800 µM for 72 h). Morphological and nuclear changes are observed, especially after 72 h compared with the untreated control cells. (B) The U251 cell line is treated with different concentrations of KPF-ABR for 24, 48, and 72 h and the inhibitory concentration (IC50) is determined using an MTT assay (1800 µM for 72 h). Morphological and nuclear changes are observed, especially after 72 h, compared with the untreated control cells. The data presented are the mean ± standard deviation of the experiments performed in triplicate.