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. 2023 Jun 27;24(13):10716. doi: 10.3390/ijms241310716

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Synergistic effect of Sophora japonica extracts before (KPF-BBR) and after bioconversion reactions (KPF-ABR) with Temozolomide (TMZ) regarding the viability of high-grade glioma cell lines. NG-97 and U251 cell lines are exposed to the isolated action of TMZ (25 to 2000 μM) for 24, 48, and 72 h. Next, cell lines are exposed to greater concentrations of TMZ in association with KPF-BBR or KPF-ABR (inhibitory concentration (IC50)). Morphological alterations are observed in both cell lines (A) NG-97 and (C) U251, suggesting apoptosis stimulation. The cell viability of (B) NG-97 and (D) U251 cell lines is measured using the MTT assay after TMZ plus KPF-BBR or KPF-ABR exposure, and it is observed to have a synergistic effect. The data presented are the mean ± standard deviation of the experiments performed in triplicate. The T-test indicates p-values ≤ 0.05.