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. 2023 Jul 6;24(13):11135. doi: 10.3390/ijms241311135

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of the Sirtuin-1 Agonist SRT2104 on intrinsic (relative to CS activity) mitochondrial capacities as measured by high-resolution respirometry in the gastrocnemius muscle of hindlimb unloaded rats. (A) Intrinsic proton LEAK, (B,C) oxidative phosphorylation supported by complex I (P_CI and P_CIG), (D) maximal coupled oxidative phosphorylation (P_CI+II), (E) maximal noncoupled electron transfer (E_CI+II), and (F) electron transfer supported by complex II only (E_CII) capacities in the gastrocnemius muscle of ambulatory control rats (CON; n = 6), rats hindlimb unloaded for 10 days (HU; n = 6), and hindlimb unloaded for 10 days while treated with SRT2104 (SIRT; n = 4). Values are means ± SEM. ns indicates no significant difference (p > 0.05).