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. 2023 Jul 6;24(13):11135. doi: 10.3390/ijms241311135

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of the Sirtuin-1 Agonist SRT2104 on mitochondrial flux control ratios in the gastrocnemius muscle of hindlimb unloaded rats. (A) The ratio of LEAK to maximal electron transfer (flux control ratio; FCR_LEAK), (B) FCR for oxidative phosphorylation supported by complex I (FCR_PCI), (C) FCR when glutamate was added as an additional complex I substrate (FCR_PCIG), (D) FCR for maximal coupled oxidative phosphorylation (FCR_PCI+II) and (E) FCR for noncoupled electron transfer supported by complex II only (FCR_ECII) of ambulatory control rats (CON; n = 6), rats hindlimb unloaded for 10 days (HU; n = 6), and rats hindlimb unloaded for 10 days while treated with SRT2104 (SIRT; n = 4). Values are means ± SEM. ns indicates no significant difference (p > 0.05).