ROS |
Reactive Oxygen Species |
SIRT1 |
Sirtuin 1 |
SRT2104 |
SIRT1 activator |
CON |
Control |
HU |
Hindlimb Unloading |
Nox2 |
NADPH oxidase-2 |
H2O2
|
hydrogen peroxide |
PGC-1α |
peroxisome proliferator-activated receptor γ coactivator-1α |
CS |
Citrate synthase |
CCO |
cytochrome c oxidase |
FCR |
flux control ratio |
PCI
|
oxidative phosphorylation supported by complex I |
PCI+II
|
maximal coupled oxidative phosphorylation |
ECI+II
|
maximal noncoupled electron transfer |
ECII
|
electron transfer supported by complex II only |
SOD |
Superoxide dismutase |
GPx |
glutathione peroxidase |
ATP |
adenosine triphosphate |
MIM |
mitochondrial isolation medium |