Skip to main content
. 2023 Jun 30;24(13):10959. doi: 10.3390/ijms241310959

Figure 12.

Figure 12

Cell death activated in response to MM134 (and presumably other pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides (MM-compounds)). The treatment of cells with MM134 induces up-regulation of tumor necrosis factor (TNF) and the tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A; TNF-R1). This event contributes to apoptosis or necroptosis induction with distinct features. Abbreviations: RIPK1/2/3—receptor-interacting serine/threonine kinase 1/2/3; TRADD—tumor necrosis factor receptor type 1-associated DEATH domain; CASP8—caspase-8; MLKL—mixed lineage kinase domain-like pseudokinase.