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Upregulation of growth arrest and DNA-damage-inducible, alpha (GADD45A) in response to DNA damage induced by MM-compounds and inhibition of serine/threonine-protein kinase AKT (as indicated by in silico studies) leads to the activation of cyclin-dependent kinase inhibitor 1 (P21) and disruption of cyclin-dependent kinase 1-cyclin B1 (CDK1-cyclin B1) proteins, contributing to cell cycle proliferation inhibition through G1/S and G2/M phase cell-cycle arrest.
