Table 1.
Differentially expressed genes (p < 0.05) between MM134-treated cells and control (DMSO-treated cells). Upregulated genes str marked in red, while down-regulated str indicated in green.
| Gene Symbol | Description | Fold Regulation | p-Value |
|---|---|---|---|
| BCL10 | B-cell CLL/lymphoma 10 | 2.50 | 0.019800 |
| GADD45A | Growth arrest and DNA-damage-inducible, alpha | 6.24 | 0.000393 |
| RIPK2 | Receptor-interacting serine-threonine kinase 2 | 2.83 | 0.002422 |
| TNF | Tumor necrosis factor | 2.96 | 0.042660 |
| TNFRSF10B | Tumor necrosis factor receptor superfamily, member 10b | 4.36 | 0.001260 |
| TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A | 2.18 | 0.018576 |
| ABL1 | C-abl oncogene 1, non-receptor tyrosine kinase | −2.65 | 0.006966 |
| AIFM1 | Apoptosis-inducing factor, mitochondrion-associated, 1 | −2.48 | 0.001081 |
| APAF1 | Apoptotic peptidase activating factor 1 | −2.74 | 0.002161 |
| BAD | BCL2-associated agonist of cell death | −2.36 | 0.006358 |
| BAG1 | BCL2-associated athanogene | −2.11 | 0.006014 |
| BCL2L10 | BCL2-like 10 (apoptosis facilitator) | −2.38 | 0.019800 |
| BIRC5 | Baculoviral IAP repeat containing 5 | −5.01 | 0.003025 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | −2.04 | 0.009433 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | −2.01 | 0.005716 |
| CASP1 | Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | −3.76 | 0.033341 |
| CASP14 | Caspase 14, apoptosis-related cysteine peptidase | −2.83 | 0.000610 |
| CASP2 | Caspase 2, apoptosis-related cysteine peptidase | −2.63 | 0.009949 |
| CASP6 | Caspase 6, apoptosis-related cysteine peptidase | −2.87 | 0.016235 |
| CD27 | CD27 molecule | −3.05 | 0.001928 |
| CD70 | CD70 molecule | −3.67 | 0.000879 |
| CIDEA | Cell death-inducing DFFA-like effector a | −2.03 | 0.001025 |
| CIDEB | Cell death-inducing DFFA-like effector b | −2.15 | 0.002795 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | −3.37 | 0.001127 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | −2.34 | 0.020318 |
| FADD | Fas (TNFRSF6)-associated via death domain | −3.68 | 0.000243 |
| FAS | Fas (TNF receptor superfamily, member 6) | −5.41 | 0.000181 |
| NAIP | NLR family, apoptosis inhibitory protein | −6.35 | 0.025237 |
| NOD1 | Nucleotide-binding oligomerization domain containing 1 | −3.13 | 0.000604 |
| PYCARD | PYD and CARD domain containing | −2.41 | 0.010219 |
| TNFRSF11B | Tumor necrosis factor receptor superfamily, member 11b | −3.85 | 0.000160 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | −6.25 | 0.000372 |
| TP53 | Tumor protein p53 | −3.84 | 0.023076 |