Table VI.

Definition of Cribriform Glands.

ISUP
“A confluent sheet of contiguous malignant epithelial cells with multiple glandular lumina that are easily visible at low power (objective magnification ×10). There should be no intervening stroma or mucin separating individual or fused glandular structures.”
Shah et al.
Features diagnostic of cribriform glands	Features against diagnosis of cribriform glands
Transluminal bridging	Partial bridging
Lack of intraglandular mucin	Presence of mucinous fibroplasia
Lack of contact between the majority of intraglandular cells with stroma	Majority of intraglandular cells in contact with stroma; stroma/vessels within the mass
A clear luminal space along the periphery of gland occupying < 50% of gland circumference	A clear luminal space along the periphery of gland occupying > 50% of gland circumference
Dense cellular proliferation (cell mass ≥ 50% of glandular lumen)	Single attachment to gland border by tumor cells forming “glomeruloid like” pattern