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Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) shows solid and cystic areas (A). The cells have eosinophilic cytoplasm and indistinct borders (B). Cytoplasmic stippling (or coarse cytoplasmic granules) is a helpful and virtually ever-present finding (C). CK20 is diffusely or focally positive (D).
