Table 2.
Baseline characteristics and univariable Cox regression analysis for cancer incidence.
| Cancer Event | HR | 95% CI | p-Value | ||
|---|---|---|---|---|---|
| Yes (n = 67) | No (n = 683) | ||||
| Age, years | 68 [63–72] | 65 [59–70] | 1.053 | 1.020–1.087 | 0.001 |
| Male gender, n (%) | 56 (84) | 597 (87) | 0.720 | 0.377–1.376 | 0.320 |
| Cardiovascular risk factors | |||||
| Family history, n (%) | 33 (49) | 380 (56) | 0.772 | 0.478–1.246 | 0.290 |
| Smoking habit, n (%) | 47 (70) | 414 (61) | 1.476 | 0.874–2.491 | 0.145 |
| Diabetes, n (%) | 10 (15) | 101 (15) | 1.050 | 0.536–2.057 | 0.887 |
| Hypertension, n (%) | 28 (42) | 333 (49) | 0.770 | 0.474–1.252 | 0.292 |
| Dysplipidemia, n (%) | 49 (73) | 469 (69) | 1.205 | 0.702–2.068 | 0.499 |
| Obesity, n (%) | 24 (36) | 194 (28) | 1.397 | 0.847–2.302 | 0.190 |
| Previous AMI, n (%) | 36 (52) | 354 (54) | 0.881 | 0.538–1.444 | 0.616 |
| Number of revascularization procedures | |||||
| <2, n (%) | 52 (78) | 581 (85) | Reference | ||
| ≥2, n (%) | 15 (22) | 102 (15) | 1.628 | 0.916–2.894 | 0.096 |
| Circulating biomarkers | |||||
| LTL | 1.01 [0.67–1.29] | 1.00 [0.70–1.40] | 0.952 | 0.643–1.409 | 0.806 |
| mtDNAcn | 33 [19–49] | 29 [18–45] | 1.000 | 0.994–1.005 | 0.871 |
| NLR | 2.10 [1.63–2.70] | 2.10 [1.61–2.77] | 0.927 | 0.739–1.163 | 0.512 |
| SII, 109/L | 521 [376–699] | 483 [353–642] | 1.000 | 0.999–1.001 | 0.896 |
AMI: acute myocardial infarction; LTL: leukocyte telomere length; mt: mitochondrial; cn: copy number; NLR: neutrophil-to-lymphocyte ratio; SII: systemic immune-inflammation index; HR: hazard ratios; CI: confidence intervals.