Table 3.
Clinical and immunological findings at diagnosis of patients with a final diagnosis of persistent PID vs. THI.
| Persistent PIDs (13 pts) |
THI (10 pts) |
Univariate Analysis p-Value |
Logistic Regression p-Value |
|
|---|---|---|---|---|
| Positive Family History for PID | 5/13 (38%) | 1/10 (10%) | ns | |
| CLINICAL MANIFESTATIONS | ||||
| Infections | 12/13 (92%) | 10/10 (100%) | ns | |
| LRTI | 8/12 (67%) | 2/10 (20%) | 0.04 | <0.05 |
| Allergy | 4/13 (31%) | 3/10 (30%) | ns | |
| Autoimmunity | 1/13 (8%) | 1/10 (10%) | ns | |
| IMMUNOLOGICAL ABNORMALITIES | ||||
| Isolated or combined IgG defect | 11/13 (85%) | 8/10 (80%) | ns | |
| Isolated or combined IgA defect | 11/13 (85%) | 3/10 (30%) | 0.0013 | <0.05 |
| Isolated or combined IgM defect | 6/13 (46%) | 3/10 (30%) | ns | |
| IgG subclass defect | 5/5 (100%) | 2/4 (50%) | ns | |
| Low anti PCP antibody response | 7/11 (64%) | 0/8 (0%) | 0.0128 | <0.05 |
| Low switched memory B cells | 7/13 (54%) | 0/5 (0%) | ns | |
| Low IgM memory B cells | 1/13 (8%) | 0/5(0%) | ns |
LRTI lower respiratory tract infections; PCP pneumococcal.