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. 2023 Jul 2;12(13):4446. doi: 10.3390/jcm12134446

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The role of circCHFR in the pathogenesis of atherosclerosis. Sponging of several miRNAs by circCHFR has been shown to lead to (1) increased cellular proliferation, migration, invasion, inflammation, and reduced cell cycle survival—all mechanisms known to contribute to atherosclerosis development [43,85,128]. However, circCHFR has also been demonstrated to (2) reduce the expression of miR-370 [21], the inhibition of which has also been shown to have opposing effects compared to circCHFR via sponging by (3) circ-BANP and (4) circ_0124644 [45,121]. (5) Disinhibition of mir-370 also likely adversely affects sinus node function in patients with heart failure [151].