Table 1.
Summarized population and treatment characteristics at inclusion.
| Overall (N=1565) | RILI+ (N=38) |
RILI- (N=1527) |
P-values | |
|---|---|---|---|---|
| Age, yrs | 0.37 (3) | |||
| Median (Range) | 55.5 (23.3, 84.4) | 54.3 (27.6, 74.1) | 55.5 (23.3, 84.4) | |
| Missing | 10 | 0 | 10 | |
| Cardiovascular disease record, N (%) | 0.03 (1) | |||
| No | 1070 (70%) | 32 (86%) | 1038 (70%) | |
| Yes | 449 (30%) | 5 (14%) | 444 (30%) | |
| Missing | 46 | 1 | 45 | |
| Respiratory disease record, N (%) | < 0.01 (1) | |||
| No | 1314 (87%) | 26 (70%) | 1288 (87%) | |
| Yes | 205 (13%) | 11 (30%) | 194 (13%) | |
| Missing | 46 | 1 | 45 | |
| * Type of respiratory history : | ||||
| Asthma | 105 (7%) | 3 (8%) | 103 (7%) | 0,74 (1) |
| COPD | 15 (1%) | 2 (5%) | 13 (1%) | 0,053 (1) |
| Tuberculosis | 17 (1%) | 1 (3%) | 16 (1%) | 0,34 (1) |
| History of acute pneumonia | 17 (1%) | 2 (5%) | 15 (1%) | 0,07 (1) |
| Interstitial syndrome | 3 (0,1%) | 0 (0%) | 3 (0%) | 1 (1) |
| other | 87 (6%) | 4 (11%) | 66 (4%) | 0,10 (1) |
| Patients with multiple respiratory diseases | 20 (1%) | 1 (3%) | 19 (1%) | 0,39 (1) |
| Tumor Size (pT)*, N (%) | < 0.01 (2) | |||
| 0 | 14 (1%) | 0 (0%) | 14 (1%) | |
| 1 | 1042 (67%) | 16 (42%) | 1026 (68%) | |
| 2 | 421 (27%) | 17 (45%) | 404 (27%) | |
| 3 | 78 (5%) | 5 (13%) | 73 (5%) | |
| Missing | 10 | 0 | 10 | |
| Nodal Status (pN)*, N (%) | < 0.01 (2) | |||
| 0 | 1035 (66%) | 16 (42%) | 1019 (67%) | |
| 1 | 408 (26%) | 14 (37%) | 394 (26%) | |
| 2 | 85 (5%) | 6 (16%) | 79 (5%) | |
| 3 | 35 (2%) | 2 (5%) | 33 (2%) | |
| Missing | 2 | 0 | 2 | |
| Type of Surgery, N (%) | 0.02 (2) | |||
| Tumorectomy | 1218 (80%) | 25 (66%) | 1243 (79%) | |
| Mastectomy | 298 (20%) | 12 (32%) | 310 (20%) | |
| Bilateral Mastectomy | 3 (0%) | 0 (0%) | 3 (0%) | |
| Bilateral Tumorectomy | 7 (0%) | 0 (0%) | 7 (0%) | |
| Tumorectomy and Mastectomy | 1 (0%) | 1 (3%) | 2 (0%) | |
| Chemotherapy, N (%) | < 0.01 (1) | |||
| No | 724 (46%) | 9 (24%) | 715 (47%) | |
| Yes | 839 (54%) | 29 (76%) | 810 (53%) | |
| Missing | 2 | 0 | 2 | |
| Nodal area radiation therapy, N (%) | < 0.01 (1) | |||
| No | 1004 (64%) | 15 (39%) | 989 (65%) | |
| Yes | 561 (36%) | 23 (61%) | 538 (35%) | |
| Missing | 0 | 0 | 0 | |
| Internal mammary chain radiation therapy, N (%) | < 0.01 (1) | |||
| No | 1085 (69%) | 17 (45%) | 1068 (70%) | |
| Yes | 480 (31%) | 21 (55%) | 459 (30%) | |
| Missing | 0 | 0 | 0 |
1. Pearson’s Chi-squared test.
2. Fisher’s Exact Test for Count Data.
3 Wilcoxon test.
*TNM 7 (2010) version, COPD: Chronic Obstructive Pulmonary Disease. N: number of patients. RILI+: Radio-Induced Lung Injury presenting patients. RILI-: Radio-Induced Lung Injury negative patients.
Bold values show statistically significant variables.