Table 3.
Multivariable analyses of RILI – associated factors (Logistic Regression).
| Variables | n/N | OR | 95% CI | P values | AIC | BIC |
|---|---|---|---|---|---|---|
|
Baseline respiratory disease
Chemotherapy Nodal RT Dmean |
11/205
29/839 23/561 |
3.041.67 1.96 1.06 |
[1.46, 6.31]
[0.70, 4.01] [0.89, 4.34] [0.99, 1.13] |
<0.01
0.25 0.10 0.08 |
335 | 361 |
|
Baseline respiratory disease
Chemotherapy Nodal RT V 5 Gy |
11/205
29/839 23/561 |
2.97
1.80 1.70 1.01 |
[1.43,6.16]
[0.75, 4.31]v[0.52, 5.54] [0.99, 1.03] |
<0.01
0.19 0.38 0.49 |
337 | 364 |
|
Baseline respiratory disease
Chemotherapy Nodal RT V 10 Gy |
11/205
29/839 23/561 |
2.95
1.84 2.20 1.01 |
[1.42,6.13]
[0.77, 4.41] [0.72, 6.75] [0.98, 1.03] |
<0.01
0.17 0.17 0.90 |
338 | 364 |
|
Baseline respiratory disease
Chemotherapy Nodal RT V 15 Gy |
11/205
29/839 23/561 |
3.00
1.81 1.78 1.01 |
[1.45,6.24]
[0.76, 4.33] [0.57, 5.58] [0.97, 1.05] |
<0.01
0.18 0.32 0.53 |
337 | 364 |
|
Baseline respiratory disease
Chemotherapy Nodal RT V 20 Gy |
11/205
29/839 23/561 |
3.05
1.77 1.43 1.03 |
[1.47, 6.34]
[0.74, 4.23] [0.46, 4.45] [0.98, 1.08] |
<0.01
0.20 0.54 0.24 |
336 | 363 |
|
Baseline respiratory disease
Chemotherapy Nodal RT V 25 Gy |
11/205
29/839 23/561 |
3.07
1.74 1.25 1.04 |
[1.48, 6.38]
[0.73, 4.16] [0.42, 3.72] [0.99, 1.10] |
<0.01
0.22 0.69 0.11 |
335 | 361 |
|
Baseline respiratory disease
Chemotherapy Nodal RT V 30 Gy |
11/205
29/839 23/561 |
3.05
1.72 1.21 1.06 |
[1.47, 6.34]
[0.72, 4.10] [0.44, 3.30] [1.01, 1.12] |
<0.01
0.23 0.71 0.04 |
334 | 360 |
|
Baseline respiratory disease
Chemotherapy Nodal RT V 35 Gy |
11/205
29/839 23/561 |
3.07
1.68 1.38 1.07 |
[1.48, 6.38]
[0.70, 4.01] [0.57, 3.38] [1.01, 1.14] |
<0.01
0.25 0.48 0.02 |
333 | 360 |
|
Baseline respiratory disease
Chemotherapy Nodal RT V 40 Gy |
11/205
29/839 23/561 |
3.04
1.67 1.96 1.06 |
[1.46, 6.31]
[0.70, 4.01] [0.89, 4.34] [0.99, 1.13] |
<0.01
0.25 0.10 0.08 |
335 | 361 |
n/N, number of RILI/number of patients; OR, Odds Ratio CI: Confidence Interval; RT, Radiation therapy; AIC, Akaike information criterion; BIC, Bayesian information criterion. Vx Gy: % of ipsilateral lung volume receiving x Gy. Dmean: mean dose to the ipsilateral lung (Gy); * 46 patients excluded for missing data for baseline respiratory disease (n=46) and for chemotherapy (n=2). Presented values are numerical and not EQD2. Bold values show statistically significant variables.