Table 1.
List of some studies using various mouse models to analyze the impact of ICIs in cancer.
| Serial No. | Mouse Model | Therapy Studied against Target | Cancer | References |
|---|---|---|---|---|
| 1 | BLT (bone marrow, liver, and thymus) mice | PD-1 | Bladder, renal, and urethra | [106,108] |
| 2 | PBMC (peripheral blood mononuclear cell) mice | PD-1/PD-L1 | Lung | [109] |
| 3 | NOG (NOD/Shi-scid/IL-2Rγnul; Non-Obese Diabetic Severe Combined Immunodeficiency Interleukin-2 receptor gamma chain) | PD-1 | Melanoma | [110] |
| 4 | BALB/c (Bagg Albino) mice | CTLA-4 | Renal cell carcinoma | [111] |
| 5 | NSG (NOD scid gamma mouse) mice with human immune cells engrafted after birth | PD-1/CTLA-4 | Breast cancer | [112] |
| 6 | NSG (NOD-scid Il2rg−/−) | PD-1/PD-L1 | Hepatocellular carcinoma | [100] |
| 7 | PBL-NSG (Peripheral Blood Lymphocyte-NOD Scid Gamma mouse) | PD-1 | Lung cancer | [113] |
| 8 | PDX (CD34+ HSC) (patient derived xenograft CD34+ hematopoietic stem cells mouse) | PD-1 | Lung cancer | [114] |
| 9 | NSG-CTLA-4 (NOD scid gamma cytotoxic T lymphocyte-associated protein 4) knock-in mice | CTLA-4 | Hepatocellular carcinoma | [115] |
| 10 | BALB/c-Rag2nullIl2rγnullSirpaNOD mice | PD-1 | Adrenocortical cancer | [116] |
| 11 | NOG-EXL mice | PD-1 | Lung cancer | [117] |