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. 2023 Jun 29;12(13):4399. doi: 10.3390/jcm12134399

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© 2023 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Apo AV a unique modulator of fasting and postprandial TGs: the new frontier? The locus ApoA1/C3/AIV on chromosome 11 has shown singular importance in lipid metabolism. In the past two decades, a new apo A, apoAV has been discovered and intensively studied. (1) ApoAV is 39 kDa protein synthesized exclusively by the liver which (2) circulates in HDL, VLDL, and chylomicrons but not in LDL. It circulates in extremely low concentrations but has proven to have strong activity as an LPL activator. (3) Indeed, its concentration is 1000-fold lower than that of apoB100 and 10,000 lower than that of apoAI. (4) Apo AV disrupts the inhibitory effect of the complex ANGPTL3-8, thereby (5) activating LPL. Some recent data indicate that it might also increase liver remnant uptake and removal. The figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.