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Schematic representation of Cx43 expression and phosphorylation of astrocytes in depression. (1) CORT reduced the synthesis of Cx43 and the distribution of Cx43 in the membrane in astrocytes. (2) Cx43 was degraded by a proteasome. (3) CORT reduced the distribution of Cx43 in the membrane and in the meantime increased the phosphorylation of Cx43 at Ser368 in the prefrontal cortical astrocytes and hippocampal astrocytes, thereby inhibiting the communication mediated by gap junctions.
