Table 1.

Summary table of the expression and phosphorylation of Cx43 in multiple diseases.

	Disease Types	Expression	Phosphorylation	Site	Function	References
The nervous system	Depression	↓	↑	Ser368, Ser279 Tyr247, Tyr265	GJCs↓	[31,32,33,34,35,36]
	AD	↑	↑	Ser368, Ser365	GJCs↓ HC↑	[55,56]
	PD	↑	↑	Ser368	GJCs↓	[58,59]
	Epilepsy	↑	↑	Ser255, Ser368	GJCs↓ HC↑	[69]
	Ischemic stroke	No significant change	↑	MK4, Ser368 Ser325/328/330	GJCs↓ HC↑	[77]
	Cerebral ischemia	↑	↑	Ser368, Tyr247 Tyr265	GJCs↓	[86,90,91]
	Cerebral vasospasm	↑	↑	Ser368	GJCs↓	[94]
	Cancer	↓	↑	serine	GJCs↓	[97,99,100]
The cardiovascular system	Cardiac ischemia/reperfusion injury	——	↑	Ser368	GJCs↓	[114,115]
	Hypertension and cardiac hypertrophy	↑	↑	——	GJCs↓	[116,117,118,119,120,121,122,123]
	Heart failure and arrhythmia	↓	Ser255↑ Ser365, Ser325/328/330↓		GJCs↓	[124,125]
Other tissues	Endothelial tissue	↓	↑	Ser368 Ser279/282	——	[133]
	Epithelial tissues	——	↑	Ser368 Ser279/282		[135,136]
	Proliferative retinopathy	——	↑	Ser325/328/330	——	[137]
	Chronic pain	——	↑	Ser368	——	[138]

Cx43, Connexin 43; HC, hemichannel; GJIC, gap junction intercellular communication; ↑, Increase; ↓, Decrease.