Table 1.
The effects of TAB derivatives against MI/R injury in H9c2.
| Compd. | Cell Viability (% of Control) | clogP a | |||||
|---|---|---|---|---|---|---|---|
| 0 μM | 0.5 μM | 1 μM | 2 μM | 4 μM | 8 μM | ||
| TAB | 56.0 ± 0.7 | 60.2 ± 0.4 | 77.2 ± 1.1 | 68.6 ± 0.9 | 65.7 ± 0.6 | 65.5 ± 1.2 | 2.69 |
| 10 | 56.5 ± 1.3 | 58.2 ± 1.3 | 56.8 ± 0.9 | 62.5 ± 1.6 | 62.0 ± 0.8 | 59.5 ± 1.4 | 4.20 |
| 11 | 56.3 ± 0.8 | 60.5 ± 0.7 | 60.4 ± 0.6 | 61.7 ± 1.2 | 67.4 ± 0.5 | 64.3 ± 0.6 | 3.58 |
| 12a | 56.6 ± 1.5 | 72.5 ± 0.5 | 75.7 ± 1.2 | 77.3 ± 1.5 | 74.6 ± 0.9 | 75.3 ± 1.1 | 3.99 |
| 12b | 56.4 ± 0.5 | 68.6 ± 1.5 | 70.7 ± 1.4 | 73.8 ± 0.9 | 77.3 ± 1.1 | 70.6 ± 0.7 | 2.71 |
| 12c | 56.7 ± 0.9 | 73.6 ± 0.5 | 78.5 ± 0.8 | 82.6 ± 1.1 | 80.4 ± 1.3 | 79.5 ± 0.8 | 3.48 |
| 12d | 56.5 ± 0.5 | 71.0 ± 0.6 | 75.6 ± 1.1 | 74.6 ± 0.8 | 72.5 ± 1.6 | 59.6 ± 1.7 | 3.70 |
| 12e | 56.1 ± 0.7 | 69.4 ± 1.2 | 74.1 ± 1.5 | 75.9 ± 1.2 | 73.7 ± 0.7 | 65.2 ± 0.3 | 2.64 |
| 12f | 56.7 ± 0.3 | 63.3 ± 1.3 | 68.5 ± 0.6 | 68.3 ± 1.0 | 66.2 ± 1.6 | 60.9 ± 1.2 | 4.46 |
| 14a | 56.9 ± 1.1 | 55.6 ± 1.0 | 57.4 ± 1.1 | 57.1 ± 1.4 | 59.7 ± 0.4 | 61.5 ± 1.1 | 4.62 |
| 14b | 56.4 ± 1.4 | 58.4 ± 1.6 | 56.1 ± 1.2 | 57.4 ± 1.7 | 58.5 ± 1.8 | 62.5 ± 0.8 | 6.41 |
| 15 | 56.0 ± 1.2 | 60.3 ± 1.0 | 64.8 ± 0.5 | 71.8 ± 1.4 | 69.3 ± 1.1 | 63.9 ± 0.9 | 4.00 |
| 16a | 55.8 ± 0.5 | 65.1 ± 0.6 | 65.7 ± 1.3 | 72.6 ± 0.3 | 70.8 ± 1.2 | 69.4 ± 0.5 | 5.30 |
| 16b | 56.4 ± 0.8 | 67.3 ± 0.6 | 75.0 ± 1.2 | 72.5 ± 1.7 | 68.2 ± 0.9 | 66.3 ± 0.6 | 4.02 |
| 16c | 56.2 ± 1.6 | 64.6 ± 1.5 | 72.4 ± 1.0 | 75.3 ± 1.2 | 69.3 ± 0.3 | 63.3 ± 0.5 | 4.79 |
| 16d | 56.7 ± 0.5 | 69.5 ± 1.5 | 71.4 ± 0.6 | 72.9 ± 1.1 | 65.4 ± 0.8 | 67.2 ± 1.0 | 5.01 |
a clogP calculated by Molinspiration [35].