Table 3.
Relevant virulence genes identified in Campylobacter hepaticus RBCL71delta using RAST and virulence factor database.
| Species | Subsystem | Description | Gene | Start | Stop | Length (pb) | CF1 | CF2 | CF3 |
|---|---|---|---|---|---|---|---|---|---|
| Campylobacter hepaticus RBCL71delta* | |||||||||
| Invasion | |||||||||
| ciaB | 634,245 | 636,080 | 1836 | + | + | + | |||
| Multidrug efflux pump | |||||||||
| CmeABC multidrug efflux system | cmeA | 218,982 | 217,879 | 1,103 | + | + | + | ||
| CmeABC multidrug efflux system | cmeB | 214,757 | 217,879 | 3,123 | + | + | + | ||
| CmeABC multidrug efflux system | cmeC | 214,764 | 213,325 | 1,439 | + | + | + | ||
| CmeABC multidrug efflux system repressor | cmeR | 219,731 | 219,093 | 638 | − | − | + | ||
| MATE family efflux transporter | N/D | 386,639 | 387,955 | 1,316 | + | + | + | ||
| TolC family protein (outer membrane efflux protein) | tolC | 736,147 | 737,430 | 1,283 | − | − | − | ||
| efflux RND transporter periplasmic adaptor subunit | N/D | 737,427 | 738,167 | 740 | − | − | − | ||
| efflux RND transporter permease subunit | acrB | 738,210 | 741,188 | 2,978 | − | − | − | ||
| Resistance to fluoroquinolones | |||||||||
| DNA gyrase A | gyrA | 732,884 | 730,284 | 2,601 | + | + | + | ||
| DNA gyrase B | gyrB | 2,573 | 4,882 | 2,309 | + | + | + | ||
| Resistance to heavy metals | |||||||||
| Magnesium and cobalt transport protein | N/D | 473,267 | 472,299 | 969 | + | + | + | ||
| CopG protein – copper homeostasis | copG | 38,111 | 38,554 | 443 | + | + | + | ||
| cobalt-zinc-cadmium resistance | N/D | 672,672 | 671,785 | 888 | + | + | + | ||
| Copper homeostasis and tolerance | cutE | 794,054 | 795,175 | 1,122 | + | + | + | ||
| Heavy metal translocation P-type ATPase | zntA | 860,168 | 857,817 | 2,352 | + | + | + | ||
| 865,803 | 863,698 | 2,106 | + | + | + | ||||
| Multicopper oxidase | cueO | 1,250,462 | 1,248,933 | 1,530 | + | + | + | ||
| Heavy metal associated domain | N/D | 1,276,002 | 1,276,661 | 660 | + | + | + | ||
| Multidrug resistance transporter, Bcr/CflA family | N/D | 1,388,967 | 1,387,762 | 1,205 | − | − | − | ||
| Magnesium and cobalt efflux protein | N/D | 1,499,625 | 1,500,911 | 1,287 | + | + | + | ||
| Bacteriocins | |||||||||
| colicin V production | cvpA | 245,976 | 246,533 | 557 | + | + | + | ||
| tRNA pseudouridine synthase A | truA | 562,338 | 563,060 | 722 | + | + | + | ||
| Dihydrofolate synthase / Folylpolyglutamate synthase | N/D | 786,750 | 785,587 | 1,163 | + | + | + | ||
| Acetyl-coenzyme A carboxyl transferase beta chain | accD | 1,461,104 | 1,460,262 | 842 | + | + | + | ||
| Amidophosphoribosyltransferase | purF | 1,511,192 | 1,509,855 | 1,337 | + | + | + | ||
*All genes identified in RBCL71delta were also identified in other RBCL strains. CF1, C. fetus CITCf01; CF2, C. fetus NCTC 10354; CF3, C. fetus CFF00A031. N/D: non determined.