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Synthesis of the final compounds 33–35. Reagents and conditions: (a) 1-iodoethane or 1-iodobutane, DMF, 50 °C, 7 h; (b) methyl malonyl chloride, TEA, dry DCM, 0–5 °C, 2–6 h; (c) NaH, THF, MeOH (cat.), 60 °C, 2 h; (d) appropriate amine, toluene, reflux, 1–2 h.
