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. 2023 Jun 25;15(13):2878. doi: 10.3390/nu15132878

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chemerin-induced vasoconstriction involves both direct effects via its type 1 receptor (CMKLR1) on vascular smooth muscle cells (VSMCs), mediated via cyclic adenosine monophosphate (cAMP) reduction, upregulation of extracellular signal-regulated kinase 1/2 (ERK1/2) and reactive oxygen species (ROS), and indirect effects mediated via activation of the sympathetic nervous system. NO, generated by endothelial NO synthase (eNOS) in endothelial cells (EC), will counteract the effects of chemerin. Data are from references [24,26,28,35,143].