Table 1.
Genes and proteins that are involved in the effect of chemerin on lipid metabolism.
| Related Genes or Proteins | Disease or Model | Sample Type | Species | Reference |
|---|---|---|---|---|
| CMKLR1; IL6 | NAFLD | Liver | Human | [72] |
| hsCRP | Obesity | Serum | Human | [73] |
| CMKLR1; PPARγ | T2D | Liver, gastrocnemius | Rat | [77] |
| ERK5; p-ERK5 | Obesity | Osteoclast | Mouse | [78] |
| PI3K; AKT; p-AKT | Obesity | Kupffer cells | Mouse | [79] |
| insulin; CCRL2; AKT; p-AKT; ERK; p-ERK | Obesity | Visceral adipose tissue | Mouse | [80] |
| CMKLR1; ERK1; ERK2; PPARγ; adiponectin; perilipin; FASN; HSL; GLUT4; IR; TNFα; IL6; leptin; UCP1 | Obesity; adipogenesis | Adipocytes (3T3-L1; brown adipose tissue) | Mouse | [81] |
| PPARγ; adiponectin; FAS; perilipin; leptin | Adipogenesis | Adipose tissue | Mouse | [82] |
| GPR1; GLUT3; AKT; p-AKT; PPARγ; FABP4 | GDM; obesity | Placenta | Human; Mouse | [83] |
| Insulin; AKT; p-AKT | Insulin challenge | Adipocytes (3T3-L1; primary human adipocytes) | Human; Mouse | [86] |
| Insulin; AKT; p-AKT | T2D; obesity | Human vascular smooth muscle cells, mouse aortas | Human; Mouse | [89] |
| CMKLR1; insulin; IRS1; p-IRS1 | T2D | Liver, adipose tissue | Mouse | [90] |
| HSL; LPL; leptin; PPARγ; CEBPα; FABP4 | Adipogenesis | Bovine intramuscular adipocytes | Bovine | [108] |
| Cyclophilin D; UCP1; UCP2; PRDM16; PEPCK; DGAT-2; DIO-2 | Obesity | Brown adipose tissue | Mouse | [109] |
| CMKLR1; TNFα; IL-1β; NFkB; PI3K; AKT; p-AKT | Pre-eclampsia | Placenta | Mouse | [110] |
| GPR1; SREBP1c; FASN; ACC1; DGAT-2; SCD-1; TNFα; IL6; SOCS3 | NAFLD | Human hepatoma cell line HepG2 | Human | [112] |
Abbreviations. CMKLR1, chemerin-like receptor 1; IL6, interleukin 6; hsCRP, high-sensitivity C-reactive protein; PPARγ, peroxisome proliferator-activated receptor γ; ERK, extracellular signal-regulated kinase; p-ERK, phosphate extracellular signal-regulated kinase; PI3K, phosphoinositide 3-kinase; AKT, protein kinase B; p-AKT, phosphate protein kinase B; CCRL2, CC motif chemokine receptor-like 2; FASN, fatty acid synthase; HSL, hormone-sensitive lipase; GLUT4, glucose transporter type 4; GLUT3, glucose transporter type 3; IR, insulin receptor; TNFα, tumor necrosis factor alpha; UCP, uncoupling protein; GPR1, chemerin type 2 receptor; FABP4, fatty acid-binding protein 4; IRS1, insulin receptor substrate-1; p-IRS1, phosphate insulin receptor substrate-1; LPL, lipoprotein lipase; CEBPα, enhancer-binding protein alpha; PRDM16, positive regulatory domain zinc finger region protein 16; PEPCK, phosphoenolpyruvate carboxykinases; DGAT-2, diacylglycerol O-acyltransferase 2; DIO-2, type II iodothyronine deiodinase; NFκB, nuclear factor-κB; SREBP1c, sterol regulatory element-binding protein 1; ACC1, acetyl-CoA carboxylase 1; SCD-1, stearoyl-CoA-desaturase 1; SOCS3, suppressor of Cytokine Signaling-3; T2D, type 2 diabetes; GDM, gestational diabetes mellitus.