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Synthesis of quinazoline derivatives 4a–na. Reagents and conditions: (a) bis(pinacolato)diboron, Sphos, Pd2(dba)3, potassium acetate, 1,4-dioxane, 100 °C, 12 h, quant.; (b) 6-bromoquinazoline, Pd(dppf)Cl2∙DCM, Cs2CO3, 1,4-dioxane/H2O (9/1), 110 °C, 12 h, 12%; (c) RNCO, DIPEA, THF, 60 °C, 12 h, 18–68%.
