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. 2023 Jul 5;28(13):5220. doi: 10.3390/molecules28135220

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic illustration of a CCC separation in heart-cut mode with two heart-cuts (HC) separated simultaneously in the 2nd dimension. (a) Pre-separation of the target compounds of HC 1 + 2 in the 1st separation. (b,c) Transfer of HC 1 to the 2nd dimension. (d) Only elution of the 1st dimension (HC 2 to the end of the 1st dimension). (e) Transfer of HC 2 to the 2nd dimension and the simultaneous separation of HC 1. (f) Simultaneous separation of HC 1 and HC 2 in the 2nd dimension. Simultaneous separation of HC 2 and fractionation of HC 1 (g). Separation of HC 2 in the 2nd dimension (h) with subsequent fractionation (i).