Table 1.
Common targets of BPH-LY and CUR interconnection.
| No. | Target | Common Name | Uniprot ID |
|---|---|---|---|
| 1 | Androgen receptor | AR | P10275 |
| 2 | Estrogen receptor alpha | ESR1 | P03372 |
| 3 | Cytochrome P450 19A1 | CYP19A1 | P11511 |
| 4 | Estrogen receptor beta | ESR2 | Q92731 |
| 5 | Vitamin D receptor | VDR | P11473 |
| 6 | Retinoic acid receptor beta | RARB | P10826 |
| 7 | MAP kinase ERK2 | MAPK1 | P28482 |
| 8 | MAP kinase p38 alpha | MAPK14 | Q16539 |
| 9 | Histone deacetylase 1 | HDAC1 | Q13547 |
| 10 | Dual-specificity phosphatase Cdc25A | CDC25A | P30304 |
| 11 | Peroxisome proliferator-activated receptor alpha | PPARA | Q07869 |
| 12 | Retinoic acid receptor alpha | RARA | P10276 |
| 13 | Epidermal growth factor receptor erbB1 | EGFR | P00533 |
| 14 | Serine/threonine-protein kinase AKT | AKT1 | P31749 |
| 15 | Serine/threonine-protein kinase B-raf | BRAF | P15056 |
| 16 | Apoptosis regulator Bcl-2 | BCL2 | P10415 |
| 17 | Signal transducer and activator of transcription 3 | STAT3 | P40763 |
| 18 | Cyclooxygenase-2 | PTGS2 | P35354 |
| 19 | TNF-alpha | TNF | P01375 |
| 20 | Tyrosine-protein kinase JAK2 | JAK2 | O60674 |
| 21 | Matrix metalloproteinase 9 | MMP9 | P14780 |
| 22 | Histone acetyltransferase p300 | EP300 | Q09472 |
| 23 | Serine/threonine-protein kinase RAF | RAF1 | P04049 |
| 24 | Matrix metalloproteinase 14 | MMP14 | P50281 |
| 25 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | P37058 |
| 26 | DNA topoisomerase II alpha | TOP2A | P11388 |
| 27 | Matrix metalloproteinase 7 | MMP7 | P09237 |
| 28 | Alkaline phosphatase, tissue-nonspecific isozyme | ALPL | P05186 |
| 29 | Serine/threonine-protein kinase Aurora-A | AURKA | O14965 |
| 30 | Glycogen synthase kinase-3 beta | GSK3B | P49841 |
| 31 | Ribosomal protein S6 kinase 1 | RPS6KB1 | P23443 |
| 32 | Nuclear factor erythroid 2-related factor 2 | NFE2L2 | Q16236 |
| 33 | Matrix metalloproteinase 13 | MMP13 | P45452 |
| 34 | Tyrosine-protein kinase JAK1 | JAK1 | P23458 |
| 35 | Arachidonate 5-lipoxygenase | ALOX5 | P09917 |
| 36 | Carbonic anhydrase IX | CA9 | Q16790 |
| 37 | Cyclooxygenase-1 | PTGS1 | P23219 |
| 38 | Toll-like receptor (TLR7/TLR9) | TLR9 | Q9NR96 |
| 39 | Plasminogen activator inhibitor-1 | SERPINE1 | P05121 |
| 40 | Interleukin-8 receptor B | CXCR2 | P25025 |
| 41 | Macrophage colony stimulating factor receptor | CSF1R | P07333 |
| 42 | Sphingosine kinase 1 | SPHK1 | Q9NYA1 |
| 43 | Type-1 angiotensin II receptor (by homology) | AGTR1 | P30556 |
| 44 | HERG | KCNH2 | Q12809 |
| 45 | ADAM17 | ADAM17 | P78536 |
| 46 | Matrix metalloproteinase 3 | MMP3 | P08254 |
| 47 | Dipeptidyl peptidase IV | DPP4 | P27487 |
| 48 | Tyrosinase | TYR | P14679 |
| 49 | Aminopeptidase N | ANPEP | P15144 |
| 50 | 11-beta-hydroxysteroid dehydrogenase 1 | HSD11B1 | P28845 |
| 51 | Carbonic anhydrase II | CA2 | P00918 |
| 52 | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | P15428 |