Skip to main content
. 2023 Apr 11;237(2):206–219. doi: 10.1097/XCS.0000000000000708

Table 4.

Coagulation Parameters and Transfusion Requirements by Resuscitation Type

Measure LTOWB
(n = 624)
COMPONENT
(n = 427)
p Value
Coagulation parameter
 Within 4 h of arrival
  International normalized ratio, median [IQR] 1.21 [1.15–1.40] 1.26 [1.16–1.40] 0.20
  Prothrombin time, sec, median [IQR] 350 [244–562] 342 [228–539] 0.44
  Rapid thromboelastography*
  Kinetic time, min, median [IQR] 2.00 [1.50–2.70] 1.90 [1.50–2.50] 0.14
   >2.5 min, n (%) 128 (30.0) 72 (24.2) 0.09
  Alpha angle, degrees, median [IQR] 69.1 [63.4–73.0] 69.7 [64.3–73.5] 0.19
   <60 degrees, n (%) 72 (16.7) 41 (13.8) 0.29
  Maximum amplitude, mm, median [IQR] 56.9 [51.3–61.2] 57.6 [52.4–62.1] 0.13
   <55 mm, n (%) 176 (40.5) 113 (37.9) 0.49
  Clot lysis at 30 min, %, median [IQR] 0.00 [0.00–0.40] 0.00 [0.00–0.30] 0.42
   >3%, n (%) 8 (2.0) 8 (2.9) 0.43
  Activated clotting time, sec, median [IQR] 113 [105–128] 113 [105–128] 0.69
   >128 sec, n (%) 69 (18.5) 48 (17.1) 0.63
 Within 24 h of arrival
  International normalized ratio, median [IQR] 1.30 [1.20–1.40] 1.31 [1.20–1.50] 0.25
  Prothrombin time, sec, median [IQR] 407 [281–619] 377 [270–584] 0.25
  Rapid thromboelastography*
  Kinetic time, min, median [IQR] 1.30 [1.10–1.80] 1.30 [1.10–1.60] 0.19
   >2.5 min, n (%) 28 (7.3) 12 (4.4) 0.12
  Alpha angle, degrees, median [IQR] 74.2 [71.1–77.0] 74.6 [71.9–76.7] 0.39
   <60 degrees, n (%) 11 (2.9) 3 (1.1) 0.12
  Maximum amplitude, mm, median [IQR] 63.8 [59.3–68.1] 64.1 [60.3–67.9] 0.61
    <55 mm, n (%) 39 (10.1) 18 (6.6) 0.12
  Clot lysis at 30 min, %, median [IQR] 0.20 [0.00–0.80] 0.20 [0.00–1.30] 0.04
   >3%, n (%) 7 (1.8) 12 (4.7) 0.03
  Activated clotting time, sec, median [IQR] 113 [105–128] 113 [105–128] 0.97
   >128 sec, n (%) 67 (18.5) 37 (14.4) 0.18
Transfusion requirement, median [IQR]
 Within 4 h of arrival
  Red blood cells, units 4.00 [1.00–10.0] 5.00 [2.00–11.0] <0.001
  Plasma, units 3.00 [0.00–9.00] 3.00 [1.00–8.00] 0.15
  Platelets, units 0.00 [0.00–2.00] 0.00 [0.00–1.00] 0.56
  Whole blood, units 2.00 [1.00–3.00]
  Total, units 10.0 [4.00–23.0] 9.00 [4.00–19.0] 0.12
  Total, mL 3170 [1330–6880] 2695 [1210–5780] <0.001
 Within 24 h of arrival
  Red blood cells, units 5.00 [1.00–12.0] 5.00 [2.00–13.0] <0.001
  Plasma, units 4.00 [0.00–11.0] 4.00 [1.00–9.00] 0.36
  Platelets, units 1.00 [0.00–2.00] 0.00 [0.00–2.00] 0.21
  Whole blood, units 2.00 [1.00–3.00]
  Total, units 12.0 [4.00–27.0] 10.0 [4.00–22.0] 0.07
  Total, mL 4105 [1765–9290] 2945 [1265–6935] <0.001
*

Values are missing for n = 152 (14.5%) LTOWB patients and n = 103 (9.8%) COMPONENT patients.

Volume for each unit of red blood cells, plasma, platelets, and whole blood was estimated to be 330, 275, 250, and 500 mL, respectively.

COMPONENT, blood component resuscitation; IQR interquartile range; LTOWB low titer group O whole blood.