Table 4.
Coagulation Parameters and Transfusion Requirements by Resuscitation Type
| Measure | LTOWB (n = 624) |
COMPONENT (n = 427) |
p Value |
|---|---|---|---|
| Coagulation parameter | |||
| Within 4 h of arrival | |||
| International normalized ratio, median [IQR] | 1.21 [1.15–1.40] | 1.26 [1.16–1.40] | 0.20 |
| Prothrombin time, sec, median [IQR] | 350 [244–562] | 342 [228–539] | 0.44 |
| Rapid thromboelastography* | |||
| Kinetic time, min, median [IQR] | 2.00 [1.50–2.70] | 1.90 [1.50–2.50] | 0.14 |
| >2.5 min, n (%) | 128 (30.0) | 72 (24.2) | 0.09 |
| Alpha angle, degrees, median [IQR] | 69.1 [63.4–73.0] | 69.7 [64.3–73.5] | 0.19 |
| <60 degrees, n (%) | 72 (16.7) | 41 (13.8) | 0.29 |
| Maximum amplitude, mm, median [IQR] | 56.9 [51.3–61.2] | 57.6 [52.4–62.1] | 0.13 |
| <55 mm, n (%) | 176 (40.5) | 113 (37.9) | 0.49 |
| Clot lysis at 30 min, %, median [IQR] | 0.00 [0.00–0.40] | 0.00 [0.00–0.30] | 0.42 |
| >3%, n (%) | 8 (2.0) | 8 (2.9) | 0.43 |
| Activated clotting time, sec, median [IQR] | 113 [105–128] | 113 [105–128] | 0.69 |
| >128 sec, n (%) | 69 (18.5) | 48 (17.1) | 0.63 |
| Within 24 h of arrival | |||
| International normalized ratio, median [IQR] | 1.30 [1.20–1.40] | 1.31 [1.20–1.50] | 0.25 |
| Prothrombin time, sec, median [IQR] | 407 [281–619] | 377 [270–584] | 0.25 |
| Rapid thromboelastography* | |||
| Kinetic time, min, median [IQR] | 1.30 [1.10–1.80] | 1.30 [1.10–1.60] | 0.19 |
| >2.5 min, n (%) | 28 (7.3) | 12 (4.4) | 0.12 |
| Alpha angle, degrees, median [IQR] | 74.2 [71.1–77.0] | 74.6 [71.9–76.7] | 0.39 |
| <60 degrees, n (%) | 11 (2.9) | 3 (1.1) | 0.12 |
| Maximum amplitude, mm, median [IQR] | 63.8 [59.3–68.1] | 64.1 [60.3–67.9] | 0.61 |
| <55 mm, n (%) | 39 (10.1) | 18 (6.6) | 0.12 |
| Clot lysis at 30 min, %, median [IQR] | 0.20 [0.00–0.80] | 0.20 [0.00–1.30] | 0.04 |
| >3%, n (%) | 7 (1.8) | 12 (4.7) | 0.03 |
| Activated clotting time, sec, median [IQR] | 113 [105–128] | 113 [105–128] | 0.97 |
| >128 sec, n (%) | 67 (18.5) | 37 (14.4) | 0.18 |
| Transfusion requirement, median [IQR] | |||
| Within 4 h of arrival | |||
| Red blood cells, units | 4.00 [1.00–10.0] | 5.00 [2.00–11.0] | <0.001 |
| Plasma, units | 3.00 [0.00–9.00] | 3.00 [1.00–8.00] | 0.15 |
| Platelets, units | 0.00 [0.00–2.00] | 0.00 [0.00–1.00] | 0.56 |
| Whole blood, units | 2.00 [1.00–3.00] | — | — |
| Total, units | 10.0 [4.00–23.0] | 9.00 [4.00–19.0] | 0.12 |
| Total, mL† | 3170 [1330–6880] | 2695 [1210–5780] | <0.001 |
| Within 24 h of arrival | |||
| Red blood cells, units | 5.00 [1.00–12.0] | 5.00 [2.00–13.0] | <0.001 |
| Plasma, units | 4.00 [0.00–11.0] | 4.00 [1.00–9.00] | 0.36 |
| Platelets, units | 1.00 [0.00–2.00] | 0.00 [0.00–2.00] | 0.21 |
| Whole blood, units | 2.00 [1.00–3.00] | — | — |
| Total, units | 12.0 [4.00–27.0] | 10.0 [4.00–22.0] | 0.07 |
| Total, mL† | 4105 [1765–9290] | 2945 [1265–6935] | <0.001 |
*
Values are missing for n = 152 (14.5%) LTOWB patients and n = 103 (9.8%) COMPONENT patients.
†
Volume for each unit of red blood cells, plasma, platelets, and whole blood was estimated to be 330, 275, 250, and 500 mL, respectively.
COMPONENT, blood component resuscitation; IQR interquartile range; LTOWB low titer group O whole blood.