Table 6.
Mortality Outcomes by Time, Prehospital Probability of Death, and Resuscitation Type
| Mortality/probability* | LTOWB | COMPONENT | Model results† | ||
|---|---|---|---|---|---|
| RR | 95% CI | p Value | |||
| Hour 4, n/N (%) | |||||
| >0.05 | 24/204 (11.8) | 26/116 (22.4) | 0.52 | (0.32–0.87) | 0.01 |
| >0.10 | 18/145 (12.4) | 25/77 (32.5) | 0.38 | (0.22–0.67) | <0.01 |
| >0.20 | 15/87 (17.2) | 21/48 (43.8) | 0.39 | (0.21–0.71) | <0.01 |
| >0.35 | 11/52 (21.2) | 17/25 (68.0) | 0.26 | (0.14–0.46) | <0.001 |
| >0.50 | 10/34 (29.4) | 10/14 (71.4) | 0.35 | (0.19–0.66) | <0.01 |
| Hour 24, n/N (%) | |||||
| >0.05 | 56/257 (21.8) | 37/143 (25.9) | 0.84 | (0.59–1.20) | 0.35 |
| >0.10 | 49/181 (27.1) | 35/87 (40.2) | 0.67 | (0.47–0.97) | 0.03 |
| >0.20 | 36/112 (32.1) | 32/58 (55.2) | 0.52 | (0.35–0.76) | <0.01 |
| >0.35 | 24/68 (35.3) | 26/42 (61.9) | 0.51 | (0.33–0.80) | <0.01 |
| >0.50 | 18/43 (41.9) | 19/28 (67.9) | 0.57 | (0.35–0.93) | 0.02 |
| Day 28, n/N (%) | |||||
| >0.05 | 85/357 (23.8) | 53/197 (26.9) | 0.93 | (0.69–1.25) | 0.63 |
| >0.10 | 72/254 (28.3) | 50/138 (36.2) | 0.80 | (0.59–1.09) | 0.16 |
| >0.20 | 56/169 (33.1) | 43/91 (47.3) | 0.70 | (0.51–0.96) | 0.03 |
| >0.35 | 45/123 (36.6) | 36/55 (65.5) | 0.62 | (0.45–0.86) | <0.01 |
| >0.50 | 35/89 (39.3) | 29/40 (72.5) | 0.64 | (0.45–0.93) | 0.017 |
*
Prehospital probability of mortality was estimated by regressing mortality on demographics, injury type, Abbreviated Injury Scores, prehospital vital signs, prehospital medication, prehospital procedures, and receiving prehospital blood products on component-only patients. Parameter estimates were then applied to LTOWB patients for comparison.
†
Adjusted for age, sex, injury type, head Abbreviated Injury Scale score, prehospital hypotension, receiving any prehospital blood product, and Injury Severity Score.
c, concordance; COMPONENT, blood component resuscitation; LTOWB low-titer group O whole blood; RR relative risk.