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. 2023 Mar 13;78(2):592–606. doi: 10.1097/HEP.0000000000000334

FIGURE 1.

FIGURE 1

HBV-specific T-cell responses are related to viral control and HBsAg loss after treatment withdrawal. IFN-γ ELISpot assay was performed to assess HBV-specific T-cell responses. (A) Experimental procedures of the cultured ELISpot assays. (B and C) Dynamic view of the frequency of HBV Env-, Core-, Pol1-, Pol2-, and HBx-specific T cells in responders and relapsers, or in responders with HBsAg loss and responders with HBsAg-positive at 0, 4, 8, 24, 48, and 96 weeks after therapy withdrawal. (B and C) Mann–Whitney U test. *p < 0.05. Abbreviations: ELISpot, enzyme-linked immunosorbent spot; Env, Envelope; PBMCs, peripheral blood mononuclear cell; Pol, Polymerase; SFCs, spot-forming cells.