Table 1.
Univariate and multivariate Cox regression analysis of clinical characteristics and prognosis index in LUSC of TCGA.
| Characteristics | Patients | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Gender (male/female) | 397/141 | 1.244 (0.919–1.683) |
.157 | 1.184 (0.871–.608) |
.281 |
| Age (<=65 vs >65) |
204/329 | 1.342 (1.022–1.76) |
.034 | 1.43 (1.08–1.892) |
.012 |
| TNM stage (T3–T4/T1–T2) | 98/440 | 1.611 (1.183–2.194) |
.002 | 1.423 (0.968–2.094) |
.073 |
| Pathologic stage (III–IV/I–II) | 96/438 | 1.52 (1.121–2.059) |
.007 | 1.362 (0.938–1.979) |
.104 |
| Smoking history (current smoking/no smoking now) | 197/330 | 0.736 (0.567–0.956) |
.022 | 0.726 (0.557–0.946) |
.018 |
| Location (central/peripheral) | 154/97 | 1.238 (0.846–1.811) |
.271 | ||
| EGFR mutation (no/yes) | 293/21 | 1.027 (0.502–2.1) |
.941 | ||
| EML4-alk translocation (no/yes) | 293/9 | 0.679 (0.168–2.752) |
.588 | ||
| Radiation therapy (no/yes) | 379/51 | 1.19 (0.775–1.829) |
.426 | 0.838 (0.5–1.405) |
.503 |
| RS (high-risk/low-risk) | 269/269 | 0.69 (0.534–0.892) |
.005 | 0.654 (0.458–0.934) |
.019 |
LUSC = Lung squamous cell carcinoma, RS = risk score, TCGA = The Cancer Genome Atlas.