Table 4.
Rates of adverse events in each therapy group of H. pylori eradication.
| Items | A group, n/N (%) | B group, n/N (%) | C group, n/N (%) | Statistics | P value |
|---|---|---|---|---|---|
| Overall adverse events | 27/100 (27.0) | 34/100(34.0) | 26/99 (26.3) | 1.156* | 0.357 |
| 0.014† | 1.000 | ||||
| 1.414‡ | 0.280 | ||||
| Bitterness | 2/100 (2.0) | 23/100 (23.0) | 22/99 (22.2) | 19.182* | 0 |
| 20.160† | 0 | ||||
| 0.017‡ | 1.000 | ||||
| Nausea | 13/100 (13.0) | 3/100 (3.0) | 3/99 (3.0) | 6.793* | 0.016 |
| 6.688† | 0.016 | ||||
| Fisher§ | 1.000 | ||||
| Diarrhea | 3/100 (3.0) | 2/100 (2.0) | 1/99 (1.0) | Fisher§ | 1.000 |
| Fisher§ | 0.621 | ||||
| Fisher§ | 1.000 | ||||
| Abdominal pain | 6/100 (6.0) | 1/100 (1.0) | 1/99 (1.0) | Fisher§ | 0.118 |
| Fisher§ | 0.118 | ||||
| Fisher§ | 1.000 | ||||
| Abdominal distension | 6/100(6.0) | 3/100 (3.0) | 2/99 (2.0) | Fisher§ | 0.498 |
| Fisher§ | 0.279 | ||||
| Fisher§ | 1.000 | ||||
| Anorexia | 4/100 (4.0) | 2/100 (2.0) | 0/99 (0) | Fisher§ | 0.683 |
| Fisher§ | 0.121 | ||||
| Fisher§ | 0.497 | ||||
| Rash | 3/100 (3.0) | 2/100 (2.0) | 1/99 (1.0) | Fisher§ | 1.000 |
| Fisher§ | 0.621 | ||||
| Fisher§ | 1.000 |
A group: Berberine triple therapy; B group: Vonoprazan quadruple therapy; C group: Rabeprazole quadruple therapy. *, A gourp vs. B group; †, A group vs. C group; ‡, B group vs. C group; §Fisher's exact test; H. pylori: Helicobacter pylori.