Table 4.

Summarized data of changes in different cognitive domains across studies.

Author (year)	Infectious agent	Complex attention	Executive functioning	Learning and memory	Language	Perceptual-motor ability	Social cognition
Prasad et al (2013)[36]	HSV-1		+		+
Breier et al (2018)[25]	HSV-1		=	=	=	=
Bhatia et al (2018)[24]	HSV-1	=	=	=		=	+
Otto et al (2004)[34]	CJD	+	+	+	+	+
Berende et al (2019)[23]	LD	+	=	=	+
Fallon et al (1999)[17]	LD	=		+	+
Fallon et al (2008)[29]	LD	+	+	+	+	+
Kaplan et al (2003)[31]	LD	+		+	+
Krupp et al (2003)[32]	LD	=			=

Changes in different cognitive domains reported from baseline to the last follow-up: “=” no significant change; “+” improvement; “no marks” not tested.

CJD = Creutzfeldt-Jakob disease, HSV-1 = herpes simplex virus, LD = Lyme disease.