Table 3.
Detectable 12-month differences for 80% power for the primary outcome and key secondary outcomes.
| Outcome | Baseline Mean | SD of change | Detectable mean difference (% of BL) | Power |
|---|---|---|---|---|
| Total Hip aBMD (g/cm2) | 1.06 | 0.033 | 0.023 (2.2%) | 92% |
| Femoral Neck aBMD (g/cm2) | 0.903 | 0.040 | 0.023 (2.6%) | 80% |
| Appendicular Lean Mass (kg) | 23.6 | 1.57 | 0.907 (3.8%) | 80% |
| Trabecular Hip vBMD (g/cm3) | 0.283 | 0.02 | 0.012 (4.1%) | 80% |
| Femoral Bone Strength (kN) | 2.044 | 0.065 | 0.037 (1.8%) | 80% |
| Fast-paced gait speed (m/s) | 1.20 | 0.15 | 0.087 (7.2%) | 80% |
BL: Baseline. *Assumes comparisons at α = 0.05 and 80% retention at 12 months (n = 48/group evaluable).